KMID : 1001920180610060669
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Journal of Korean Neurosurgical Society 2018 Volume.61 No. 6 p.669 ~ p.679
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Activin A/BMP2 Chimera (AB204) Exhibits Better Spinal Bone Fusion Properties than rhBMP2
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Ryu Dal-Sung
Yoon Byung-Hak Oh Chang-Hyun Kim Moon-Hang Kim Ji-Yong Yoon Seung-Hwan Choe Se-Nyon
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Abstract
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Objective: To compare the spinal bone fusion properties of activin A/BMP2 chimera (AB204) with recombinant human bone morphogenetic protein (rhBMP2) using a rat posterolateral spinal fusion model.
Methods: The study was designed to compare the effects and property at different dosages of AB204 and rhBMP2 on spinal bone fusion. Sixty-one male Sprague-Dawley rats underwent posterolateral lumbar spinal fusion using one of nine treatments during the study, that is, sham; osteon only; 3.0 ¥ìg, 6.0 ¥ìg, or 10.0 ¥ìg of rhBMP2 with osteon; and 1.0 ¥ìg, 3.0 ¥ìg, 6.0 ¥ìg, or 10.0 ¥ìg of AB204 with osteon. The effects and property on spinal bone fusion was calculated at 4 and 8 weeks after treatment using the scores of physical palpation, simple radiograph, micro-computed tomography, and immunohistochemistry.
Results: Bone fusion scores were significantly higher for 10.0 ¥ìg AB204 and 10.0 ¥ìg rhBMP2 than for osteon only or 1.0 ¥ìg AB204. AB204 exhibited more prolonged osteoblastic activity than rhBMP2. Bone fusion properties of AB204 were similar with the properties of rhBMP2 at doses of 6.0 and 10.0 ¥ìg, but, the properties of AB204 at doses of 3.0 ¥ìg exhibited better than the properties of rhBMP2 at doses of 3.0 ¥ìg.
Conclusion: AB204 chimeras could to be more potent for treating spinal bone fusion than rhBMP2 substitutes with increased osteoblastic activity for over a longer period.
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KEYWORD
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Spinal fusion, Activin A, Bone morphogenetic proteins, Fusion, Rat
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